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Oral Cancer

Although this topic is scary, this article may just save your life

By Dr. Sol Silverman, Jr.

Woman breaking a cigarette.

Cancer: Know All You Can About It

Cancer is one of the scariest words in our language. If you're one of a growing number of people determined to take an active role in your health care now and in the future, you'll want to learn what you can about one of the principal killers in developed nations today. Knowledge is power; let's arm ourselves with as much knowledge as we can. We will begin with an overview then apply the information to a more specific type: oral cancer.

What is Cancer?

Cancers are a class of diseases characterized by the uncontrolled division of cells and the ability of these cancerous cells to spread. They can grow into nearby tissue through a process known as invasion, or they can be transported through the bloodstream or lymphatic system (a complex system of glands and ducts active in the body's defense against disease), to distant areas by what is called metastasis. I'll attempt to provide what we know today about this major threat.

The scary aspect of oral cancer is that it's not usually detected until a late stage.

There are many types of cancers; how severe the symptoms are generally depends on the nature of the malignancy, which refers to cancerous cells that usually have the ability to spread, invade, and destroy tissue. Most cancers can be treated and some even cured, depending on the type, location in the body, and at what stage the cancer is diagnosed. However, once diagnosed, cancer is usually treated with a combination of surgery, “chemotherapy” (drugs which destroy cancerous cells) and “radiotherapy” (killing cancerous cells with radiation).

How is a Normal Cell Transformed?

The unregulated growth of cells that characterizes cancer is caused by damage to DNA — the stuff that genes are made of. The genes are the command machinery which informs the cells what to do. Mutations, changes to the DNA, alter and damage proper cell function. Many mutation events may take place to transform a normal cell into a malignant one. What causes these mutations to occur? They can be caused by radiation, chemicals or physical agents known as carcinogens, or by certain viruses that are able to insert their own genetic material into human cells. There are two alarming characteristics of mutations:

  • they can occur spontaneously, and
  • they may be passed down from one cell generation to the next.

Cancer: A “Multifactorial” Disease

There are many reasons or factors that cause normal cells to mutate into cancerous ones. Among the most important are:

  • predisposing factors — an innate capacity to develop disease that can be triggered under certain conditions, e.g. genetics (genes that are altered or mutate have a tendency to occur along family lines), and
  • risk factors — conditions or behaviors that increase the possibility of disease e.g. smoking, chewing tobacco and alcohol use, diets low in fruits and vegetables, viral infections — primarily the human papilloma virus “HPV 16” (the same one that's been in the news lately which causes cervical cancer in women), and an immune (protective) system that is not functioning normally in response to infections or inherited disease.

Oral Cancer & Precancerous Conditions

Now that we have more of a background about cancer, its causes as well as its risk factors, let's take that knowledge and apply it to a specific area, the mouth.

Oral cancer accounts for roughly 3% of all cancers in men and 2% in women. Men still outnumber women 2 to 1, but this is changing as women become more exposed to the same risk factors as men. Like all cancers, oral cancer is associated with aging. Did you know that more than 90% of all oral cancers occur in individuals over 40? We now know that African-Americans have a higher incidence than Caucasians and a disturbing number of cases in young people regardless of ethnicity, have been seen in recent years.

Just ponder this staggering statistic: in 2008, it is estimated that more than 34,000 cancers of the oropharynx (oro-mouth and pharynx-throat), will be diagnosed in the USA. Get familiar with the main areas where oral carcinomas (cancers) occur:

  • the oral cavity proper (the mouth),
  • the lip, tongue, and
  • the pharynx (back of the mouth and throat).

You might say that the mouth and lips are accessible for direct examination all the time by routine visits to the dentist. Thinking along those lines, it's probably easy for a dentist to notice anything unusual in the mouth within a matter of months, right? Here's the scary aspect of oral cancer: it is not usually detected until a late stage. So despite all the advances in treatment, survival is poor, with only 58% surviving 5 years after treatment.

Most oral cancers are “squamous” (small scale-shaped) cell carcinomas, occurring in the lining of the mouth and are often preceded by identifiable surface changes (lesions) of the oral membranes. White or red patches begin to form in the pre-cancerous stage, and as the cancer develops, a non-healing ulcer may appear.



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